Variability in beta-adrenergic receptor response in the vasculature: Role of receptor polymorphism.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 12464942.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
beta-adrenergic receptors (betaARs) are important in determining vascular tone. Stimulation of beta(2)ARs in the vasculature produces vasodilatation, which acts to counteract the vasoconstriction produced by endogenous sympathetic agonists. Impaired vasodilatation occurs in human hypertension and in Blacks. It is now clear that receptor polymorphism may contribute to some of the variability seen in vascular response. beta(2)AR haplotypes determine the desensitization response to chronic agonist exposure in vivo and result in altered vasodilatory responses.
Medical subject headings
- Hypertension
- Polymorphism, Genetic
- Receptors, Adrenergic, beta-1
- Receptors, Adrenergic, beta-2