Squamous metaplasia of the canaliculi associated with 5-fluorouracil: a clinicopathologic case report.
case_report · Level V
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Abstract
To illustrate a newly recognized histopathologic change in a patient with canalicular obstruction after weekly administration of 5-fluorouracil for colon cancer. Interventional case report. A full-thickness section of canaliculus was obtained during surgical repair. Histopathologic changes in the specimen. The prominent histologic feature of the canalicular specimen was severe squamous metaplasia with narrowing of the lumen. Canalicular obstruction may follow systemic use of 5-fluorouracil due to squamous metaplasia.
Medical subject headings
- Antimetabolites, Antineoplastic
- Fluorouracil
- Lacrimal Apparatus
- Lacrimal Duct Obstruction