Stomatocyte-discocyte-echinocyte sequence of the human red blood cell: evidence for the bilayer- couple hypothesis from membrane mechanics.
basic_science · Level V
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- Record sourced from PubMed, PMID 12471152.
- Also identified by PMC identifier 139218.
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Abstract
Red-cell shape is encoded in the mechanical properties of the membrane. The plasma membrane contributes bending rigidity; the protein-based membrane skeleton contributes stretch and shear elasticity. When both effects are included, membrane mechanics can reproduce in detail the full stomatocyte-discocyte-echinocyte sequence by variation of a single parameter related to the bilayer couple originally introduced by Sheetz and Singer [Sheetz, M. P. & Singer, S. J. (1974) Proc. Natl. Acad. Sci. USA 71, 4457-4461].
Medical subject headings
- Erythrocyte Membrane
- Erythrocytes
- Lipid Bilayers