Gammadelta T lymphocytosis associated with granulomatous disease in a patient with common variable immunodeficiency.
case_report · Level V
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Abstract
Common variable immunodeficiency (CVID) is a heterogeneous group of immunodeficiency syndromes that involves defective production of specific antibodies and decreased serum concentrations of > or =1 immunoglobulin isotype. We describe a patient with an atypical case of CVID who had extensive granulomatous lesions that were partially attributable to mycobacterial infection. In the peripheral blood, there was a massive increase in the number of double-negative CD3+ T cells that expressed the gammadelta T cell receptor.
Medical subject headings
- Common Variable Immunodeficiency
- Granulomatous Disease, Chronic
- Lymphocytosis
- Receptors, Antigen, T-Cell, gamma-delta