Identification of a susceptibility locus for migraine with and without aura on 6p12.2-p21.1.
basic_science · Level V
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Abstract
Migraine is the most common type of chronic episodic headache. To find novel susceptibility genes for familial migraine with and without aura, a genomewide screen was performed in a large family from northern Sweden. Evidence of linkage was obtained on chromosome 6p12.2-p21.1, with a maximum two-point lod score of 5.41 for marker D6S452. The patients with migraine shared a common haplotype of 10 Mb between markers D6S1650 and D6S1960.
Medical subject headings
- Chromosomes, Human, Pair 6
- Migraine with Aura
- Migraine without Aura