HLA-DQ8 as an Ir gene in coeliac disease.
expert_opinion · Level V
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- Record sourced from PubMed, PMID 12477747.
- Also identified by PMC identifier 1773536.
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Abstract
DQ8 restricted gliadin peptide is immunogenic in the intestinal mucosa of HLA-DQ8 positive patients, representing the first demonstration that a given peptide may be of pathogenic significance only for a subset of coeliacs, and strongly suggests that DQ2 and DQ8 act as immune response (Ir) genes in this disease
Medical subject headings
- Celiac Disease
- Genes, MHC Class II
- HLA-DQ Antigens
- Intestinal Mucosa
- Intestine, Small