Human herpesvirus 6B infection of the large intestine of patients with diarrhea.
case_report · Level V
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Abstract
Four patients had severe diarrhea after undergoing stem cell transplantation. Human herpesvirus 6B (HHV-6B) DNA was detected in large intestine tissue specimens and in peripheral blood mononuclear cells. In situ hybridization was positive for HHV-6B DNA in the nuclei of goblet cells and, sometimes, in the histiocytes in the submucous region of the large intestine, which suggests that HHV-6B may infect and reactivate in these cells.
Medical subject headings
- Diarrhea
- Herpesvirus 6, Human
- Intestinal Diseases
- Roseolovirus Infections