Presentation of a PTHrP-secreting pancreatic neuroendocrine tumour, with hypercalcaemic crisis, pre-eclampsia, and renal failure.
case_report · Level V
Where this comes from
- Record sourced from PubMed, PMID 12509695.
- Also identified by PMC identifier 1757936.
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Abstract
Severe hypercalcaemia during pregnancy is rare and most cases are secondary to hyperparathyroidism. This is the first report of a parathyroid hormone related protein (PTHrP) secreting neuroendocrine tumour of the pancreas manifesting with severe hypercalcaemia during pregnancy. Measurement of PTHrP was useful in both the diagnosis and follow up of our patient and should be considered in the diagnostic workup of patients with unexplained hypercalcaemia. A raised PTHrP concentration is a strong indicator of malignancy.
Medical subject headings
- Acute Kidney Injury
- Hypercalcemia
- Neuroendocrine Tumors
- Pancreatic Neoplasms
- Pre-Eclampsia
- Pregnancy Complications, Neoplastic