Targeting tumours with genetically enhanced T lymphocytes.
review · Level V
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- Record sourced from PubMed, PMID 12509765.
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Abstract
The genetic modification of T lymphocytes is an important approach to investigating normal T-cell biology and to increasing antitumour immunity. A number of genetic strategies aim to increase the recognition of tumour antigens, enhance antitumour activities and prevent T-cell malfunction. T cells can also be engineered to increase safety, as well as to express markers that can be tracked by non-invasive imaging technologies. Genetically modified T cells are therefore proving to be of great value for basic immunology and experimental immunotherapy.
Medical subject headings
- Immunotherapy
- Neoplasms
- T-Lymphocytes