Myoglobinuria and COX deficiency in a patient taking cerivastatin and gemfibrozil.
case_report · Level V
Where this comes from
- Record sourced from PubMed, PMID 12525734.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
The authors describe a patient who presented with myoglobinuria after starting cerivastatin-gemfibrozil therapy. Muscle histochemistry revealed ragged-red fibers and cytochrome c oxidase negative (COX) fibers, and biochemistry showed a defect of COX activity. Immunoblot analysis showed a 60% reduction of COX I and COX II polypeptides. Cerivastatin myotoxicity might be related to a depletion of essential metabolites needed to anchor COX subunit I to mitochondrial membrane.
Medical subject headings
- Cytochrome-c Oxidase Deficiency
- Gemfibrozil
- Hydroxymethylglutaryl-CoA Reductase Inhibitors
- Hypolipidemic Agents
- Myoglobinuria
- Pyridines