Longstanding ataxic demyelinating polyneuronopathy with a novel autoantibody.
case_report · Level V
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Abstract
The authors describe the clinical course, postmortem findings, and characterization of a novel autoantibody (anti-M-phase phosphoprotein-1 [anti-MPP-1]) in a patient with a longstanding acquired demyelinating polyneuropathy and neuronopathy. Postmortem examination identified active sensory neuron degeneration, sensory axon loss, and widespread peripheral nerve demyelination. A possible pathophysiologic role of anti-MPP-1 is not yet identified.
Medical subject headings
- Adenocarcinoma
- Ataxia
- Autoantibodies
- Cell Cycle Proteins
- Lung Neoplasms
- Polyradiculoneuropathy