Prediction of spontaneous autoimmune diabetes in NOD mice by quantification of autoreactive T cells in peripheral blood.
Level V
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- Record sourced from PubMed, PMID 12531877.
- Also identified by PMC identifier 151866.
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Abstract
Autoimmune (type 1) diabetes mellitus results from the destruction of insulin-producing pancreatic beta cells by T lymphocytes. Prediction of cell-mediated autoimmune diseases by direct detection of autoreactive T cells in peripheral blood has proved elusive, in part because of their low frequency and reduced avidity for peptide MHC ligands. This article was published online in advance of the print edition. The date of publication is available from the JCI website, http://www.jci.org.
Medical subject headings
- CD8-Positive T-Lymphocytes
- Diabetes Mellitus, Type 1
- Lymphocyte Count