A profile hidden Markov model for signal peptides generated by HMMER.
other · Level V
Where this comes from
- Record sourced from PubMed, PMID 12538263.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Although the HMMER package is widely used to produce profile hidden Markov models (profile HMMs) for protein domains, it has been difficult to create a profile HMM for signal peptides. Here we describe an approach for building a complex model of eukaryotic signal peptides by the standard HMMER package. Signal peptide prediction with this model gives a 95.6% sensitivity and 95.7% specificity. The profile HMM for signal peptides, data sets, and the scripts for analyzing data are available for non-commercial use at http://share.gene.com/.
Medical subject headings
- Models, Genetic
- Protein Sorting Signals
- Sequence Alignment
- Sequence Analysis, Protein