The role of nuclear factor-kappaB essential modulator (NEMO) in B cell development and survival.
basic_science · Level V
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- Record sourced from PubMed, PMID 12538858.
- Also identified by PMC identifier 298751.
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Abstract
The transcription factor nuclear factor-kappaB (NF-kappaB) is essential for immune and inflammatory responses. NF-kappaB essential modulator (NEMO) is a scaffolding component of the IkappaB kinase complex required for NF-kappaB activation in vitro. Because NF-kappaB activation is involved in B cell development and function, we set out to determine whether NEMO is required for these processes. NEMO(-/-) mice die very early during embryogenesis, and fetal livers from NEMO(-/-) embryos can not reconstitute either B or T lymphopoiesis in irradiated host mice. We therefore used NEMO(-/-) embryonic stem cells and the OP9 in vitro differentiation system to demonstrate that NEMO is not required for B cell development but plays an important role in B cell survival.
Medical subject headings
- B-Lymphocytes
- Protein Serine-Threonine Kinases