The use of topiramate in refractory status epilepticus.

Towne, A R; Garnett, L K; Waterhouse, E J; Morton, L D; DeLorenzo, R J · Neurology · 2003

case_series · Level IV

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Abstract

In cases of refractory status epilepticus (RSE) unresponsive to sequential trials of multiple agents, a suspension of topiramate administered via nasogastric tube was effective in aborting RSE, including one patient in a prolonged pentobarbital coma. Effective dosages ranged from 300 to 1,600 mg/d. Except for lethargy, no adverse events were reported.

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