Sporadic Creutzfeldt-Jakob disease with MM1-type prion protein and plaques.
case_report · Level V
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Abstract
The authors report a 75-year-old woman with atypical sporadic Creutzfeldt-Jakob disease (CJD) characterized by MM1-type prion protein (PrP) (methionine homozygosity at codon 129 in the PrP gene and type-1 protease-resistant PrP) and PrP plaques. This patient is the first case of sporadic CJD with plaque-forming MM1-type PrP, suggesting either a shared prion strain with the plaque-forming subset of dural graft-associated CJD or shared host genetic factors that are unrelated to the PrP genotype.
Medical subject headings
- Creutzfeldt-Jakob Syndrome
- Plaque, Amyloid
- Prions