Influence of factor V Leiden on the development of neovascularisation secondary to central retinal vein occlusion.
retrospective_cohort · Level III
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- Record sourced from PubMed, PMID 12598443.
- Also identified by PMC identifier 1771539.
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Abstract
To investigate if the presence of factor V Leiden has an influence on the prognosis in central retinal vein occlusion (CRVO). 166 patients with CRVO were studied retrospectively. They were tested for factor V Leiden using DNA analysis. The presence of the mutation was studied in correlation with the development of neovascular complications 1 year after the thrombotic event. 56 of 166 patients (34%) developed neovascular complications after 1 year. In the patients who had the studied mutation 11 of 20 (55%) had developed neovascular complications after 1 year, compared to 45 of 146 patients (31%) in the group without factor V Leiden (p=0.04). The presence of factor V Leiden seems to enhance the risk of developing neovascular complications in CRVO.
Medical subject headings
- Factor V
- Retinal Neovascularization
- Retinal Vein Occlusion