PopHist: inferring population history from the spectrum of allele frequencies.
basic_science · Level V
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Abstract
PopHist is a computer program that uses the frequency spectrum of alleles to: (a) estimate maximum likelihood parameters describing a population's history; and (b) compare alternative hypotheses about population history using likelihood ratio tests. The program uses the matrix coalescent, a method for calculating theoretical frequency spectra that can be applied to sets of unlinked sites. Source code and documentation are available at http://mombasa.anthro.utah.edu/wooding/PopHist
Medical subject headings
- Algorithms
- DNA Mutational Analysis
- Gene Frequency
- Population
- Population Dynamics