SET-ting the stage for life and death.
editorial · Level V
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Abstract
Cytotoxic T lymphocytes release granzymes (Gzm) A and B to induce apoptosis or programmed cell death of virally infected or tumor cells. In this issue of Cell, Fan et al. identify the tumor metastasis suppressor NM23-H1 as a GzmA-activated, apoptosis-inducing DNase and the oncoprotein SET as its inhibitor. Work from the Lieberman and Wang groups indicates a surprising role for a group of acidic nucleo-cytoplasmic proteins in regulating apoptosis.
Medical subject headings
- Apoptosis
- Chromosomal Proteins, Non-Histone
- Eukaryotic Cells
- Monomeric GTP-Binding Proteins
- Nucleoside-Diphosphate Kinase
- Serine Endopeptidases
- Signal Transduction
- Transcription Factors