Oral and genital lichenoid reactions associated with circulating autoantibodies to desmoplakins I and II: a novel target antigen or example of epitope spreading?
case_report · Level V
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Abstract
We describe the first reported case of persistent oral and genital lichenoid reactions associated with circulating antibodies to 250- and 215-kd proteins, compatible with desmoplakin I and II, respectively. We discuss the potential role of epitope spreading, leading to the novel development of specific autoantibodies to desmoplakin.
Medical subject headings
- Cytoskeletal Proteins
- Genital Diseases, Female
- Lichenoid Eruptions
- Oral Ulcer
- Ulcer