Hyperinsulinism and overgrowth without obesity.
case_report · Level V
Where this comes from
- Record sourced from PubMed, PMID 12651761.
- Also identified by PMC identifier 1719530.
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Abstract
We report a 5 year old girl with postnatal overgrowth (height velocity >97th centile), hyperinsulinaemia, and increased insulin-like growth factor 1 for age, without evidence of bioactive or immunoreactive growth hormone excess or pituitary abnormality. Although her overgrowth may be a result of hyperinsulinism, her serum contains a factor (neither insulin nor IGF-1) which is able to stimulate the proliferation of lymphocyte precursors, and this could also account for the overgrowth. Over the course of two years observation she has developed acanthosis nigricans and diabetes mellitus.
Medical subject headings
- Acromegaly
- Hyperinsulinism