Role of Polo-like kinase CDC5 in programming meiosis I chromosome segregation.
basic_science · Level V
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Abstract
Meiosis is a specialized cell division in which two chromosome segregation phases follow a single DNA replication phase. The budding yeast Polo-like kinase Cdc5 was found to be instrumental in establishing the meiosis I chromosome segregation program. Cdc5 was required to phosphorylate and remove meiotic cohesin from chromosomes. Furthermore, in the absence of CDC5 kinetochores were bioriented during meiosis I, and Mam1, a protein essential for coorientation, failed to associate with kinetochores. Thus, sister-kinetochore coorientation and chromosome segregation during meiosis I are coupled through their dependence on CDC5.
Medical subject headings
- Chromosome Segregation
- Chromosomes, Fungal
- Meiosis
- Protein Kinases
- Saccharomyces cerevisiae