Role of mobile DNA in the evolution of vancomycin-resistant Enterococcus faecalis.
basic_science · Level V
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Abstract
The complete genome sequence of Enterococcus faecalis V583, a vancomycin-resistant clinical isolate, revealed that more than a quarter of the genome consists of probable mobile or foreign DNA. One of the predicted mobile elements is a previously unknown vanB vancomycin-resistance conjugative transposon. Three plasmids were identified, including two pheromone-sensing conjugative plasmids, one encoding a previously undescribed pheromone inhibitor. The apparent propensity for the incorporation of mobile elements probably contributed to the rapid acquisition and dissemination of drug resistance in the enterococci.
Medical subject headings
- Biological Evolution
- Enterococcus faecalis
- Genome, Bacterial
- Interspersed Repetitive Sequences
- Sequence Analysis, DNA
- Vancomycin Resistance