Diminished striatal [123I]iodobenzovesamicol binding in idiopathic cervical dystonia.
case_series · Level IV
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Abstract
Striatal dysfunction is thought to underlie many dystonias. We used [(123)I]iodobenzovesamicol single-photon emission computed tomography imaging to determine the density of cholinergic terminals in the striatum and other brain regions in 13 subjects with idiopathic cervical dystonia. Striatal [(131)I]iodobenzovesamicol binding was reduced. These results support a role for striatal dysfunction in idiopathic dystonias and suggest diminished striatal cholinergic interneuron density in cervical dystonia.
Medical subject headings
- Corpus Striatum
- Membrane Transport Proteins
- Tomography, Emission-Computed, Single-Photon
- Torticollis
- Vesicular Transport Proteins