Localization of denaturation bubbles in random DNA sequences.
basic_science · Level V
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- Record sourced from PubMed, PMID 12672955.
- Also identified by PMC identifier 404689.
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Abstract
We study the thermodynamic and dynamic behaviors of twist-induced denaturation bubbles in a long, stretched random sequence of DNA. The small bubbles associated with weak twist are delocalized. Above a threshold torque, the bubbles of several tens of bases or larger become preferentially localized to AT-rich segments. In the localized regime, the bubbles exhibit "aging" and move around subdiffusively with continuously varying dynamic exponents. These properties are derived by using results of large-deviation theory together with scaling arguments and are verified by Monte Carlo simulations.
Medical subject headings
- DNA
- Nucleic Acid Denaturation