A stress sensor for the bacterial periplasm.
basic_science · Level V
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- Record sourced from PubMed, PMID 12679025.
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Abstract
DegS, the periplasmic stress sensor, becomes activated when its PDZ domain recognizes the improperly exposed C-terminal sequences of outer membrane porins. This interaction relieves the inhibition of the neighboring protease domain of DegS, triggering a proteolysis cascade that leads to the sigma(E)-driven expression of periplasmic chaperones.
Medical subject headings
- Bacteria
- Periplasm