A new role for Ran in ensuring precise duplication of chromosomal DNA.
basic_science · Level V
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- Record sourced from PubMed, PMID 12679026.
- Also identified by PMC identifier 3604807.
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Abstract
To prevent re-replication of DNA, the licensing of replication origins is inhibited in S phase and G2. New work by Yamaguchi et al. (in this issue of Cell) shows that the small GTPase Ran can directly inhibit licensing inside nuclei once CDKs are active late in the cell cycle.
Medical subject headings
- Cell Nucleus
- DNA Replication
- DNA, Complementary
- Eukaryotic Cells
- ran GTP-Binding Protein