Meningioma showing VHL gene inactivation in a patient with von Hippel-Lindau disease.
case_report · Level V
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Abstract
The genetic mechanism of the tumorigenesis of meningioma in conjunction with von Hippel-Lindau (VHL) disease is unclear. The authors present a case of VHL disease associated with a posterior fossa meningioma and with multiple cerebellar hemangioblastomas. A germline mutation of the VHL gene and loss of heterozygosity on the VHL gene locus in 3p were detected in the meningioma. Tumorigenesis of a meningioma associated with VHL disease could be caused by inactivation of both alleles of the VHL gene.
Medical subject headings
- Carcinoma, Renal Cell
- Cerebellar Neoplasms
- Hemangioblastoma
- Ligases
- Meningioma
- Neoplasms, Multiple Primary
- Tumor Suppressor Proteins
- Ubiquitin-Protein Ligases
- von Hippel-Lindau Disease