Cerebellar ataxia and coenzyme Q10 deficiency.
case_series · Level IV
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- Record sourced from PubMed, PMID 12682339.
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Abstract
The authors measured coenzyme Q10 (CoQ10) concentration in muscle biopsies from 135 patients with genetically undefined cerebellar ataxia. Thirteen patients with childhood-onset ataxia and cerebellar atrophy had markedly decreased levels of CoQ10. Associated symptoms included seizures, developmental delay, mental retardation, and pyramidal signs. These findings confirm the existence of an ataxic presentation of CoQ10 deficiency, which may be responsive to CoQ10 supplementation.
Medical subject headings
- Cerebellar Ataxia
- Ubiquinone