Defective CD8 T cell memory following acute infection without CD4 T cell help.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 12690202.
- Also identified by PMC identifier 2778341.
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Abstract
The CD8+ cytotoxic T cell response to pathogens is thought to be CD4+ helper T cell independent because infectious agents provide their own inflammatory signals. Mice that lack CD4+ T cells mount a primary CD8 response to Listeria monocytogenes equal to that of wild-type mice and rapidly clear the infection. However, protective memory to a challenge is gradually lost in the former animals. Memory CD8+ T cells from normal mice can respond rapidly, but memory CD8+ T cells that are generated without CD4 help are defective in their ability to respond to secondary encounters with antigen. The results highlight a previously undescribed role for CD4 help in promoting protective CD8 memory development.
Medical subject headings
- CD8-Positive T-Lymphocytes
- Immunologic Memory
- Listeriosis
- T-Lymphocytes, Helper-Inducer