Eosinophilic myenteric ganglionitis is associated with functional intestinal obstruction.
case_report · Level V
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- Record sourced from PubMed, PMID 12692064.
- Also identified by PMC identifier 1773648.
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Abstract
The diagnostic features and clinical course of three children (aged 1 month to 15 years) with severe functional intestinal obstruction and inflammation of the colonic lamina propria and myenteric plexus are described. The myenteric inflammatory infiltrate was eosinophil predominant with none of the immunological characteristics of lymphocytic ganglionitis. Neurones in the myenteric ganglia expressed the potent eosinophil chemoattractant interleukin 5. None responded to dietary exclusion but all three responded symptomatically to immunosuppression/anti-inflammatory treatments. Eosinophilic ganglionitis is associated with a pseudo-obstructive syndrome which is amenable to anti-inflammatory treatment.
Medical subject headings
- Autonomic Nervous System Diseases
- Eosinophilia
- Ganglia, Autonomic
- Intestinal Obstruction
- Myenteric Plexus