Axons guided by insulin receptor in Drosophila visual system.
basic_science · Level V
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Abstract
Insulin receptors are abundant in the central nervous system, but their roles remain elusive. Here we show that the insulin receptor functions in axon guidance. The Drosophila insulin receptor (DInR) is required for photoreceptor-cell (R-cell) axons to find their way from the retina to the brain during development of the visual system. DInR functions as a guidance receptor for the adapter protein Dock/Nck. This function is independent of Chico, the Drosophila insulin receptor substrate (IRS) homolog.
Medical subject headings
- Axons
- Carrier Proteins
- Drosophila
- Intracellular Signaling Peptides and Proteins
- Photoreceptor Cells, Invertebrate
- Protein-Tyrosine Kinases
- Receptor Protein-Tyrosine Kinases
- Receptor, Insulin