TB or Not TB: how Mycobacterium tuberculosis may evade drug treatment.
editorial · Level V
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Abstract
In this issue of Cell, a study by Valerie Mizrahi and her colleagues suggests that a putative error-prone DNA polymerase encoded by the dnaE2 gene of Mycobacterium tuberculosis may bypass certain types of DNA base damage, generating mutations. This may be an important mechanism for generating drug-resistant strains of M. tuberculosis.
Medical subject headings
- DNA-Directed DNA Polymerase
- Drug Resistance, Bacterial
- Mutation
- Mycobacterium tuberculosis
- Tuberculosis, Multidrug-Resistant