Another tie that binds the MTA family to breast cancer.
editorial · Level V
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Abstract
In this issue of Cell, demonstrate that MTA3 is an estrogen-dependent component of the NuRD complex and identify the Snail gene as its direct target. ER signaling upregulates MTA3 levels to negatively modulate Snail-mediated repression of E-cadherin. These findings may explain how ER status controls epithelial-to-mesenchymal transition in human breast tumors.
Medical subject headings
- Breast Neoplasms
- Cell Transformation, Neoplastic
- Gene Expression Regulation, Neoplastic
- Neoplasm Proteins