Muscle or fat? Rho bridges the GAP.
basic_science · Level V
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- Record sourced from PubMed, PMID 12705863.
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Abstract
Mesenchymal stem cells can differentiate into muscle or fat cells, depending on the exposure to growth factors. The Rho GTPase appears to play a crucial role in this decision of cellular fate, promoting myogenesis and inhibiting adipogenesis.
Medical subject headings
- Adipose Tissue
- Guanine Nucleotide Exchange Factors
- Muscle, Skeletal
- Nuclear Proteins