A new type I IFN-mediated pathway for the rapid differentiation of monocytes into highly active dendritic cells.
Where this comes from
- Record sourced from PubMed, PMID 12743330.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Dendritic cells (DCs) are a unique leukocyte type consisting of different subsets of professional antigen-presenting cells. Since DCs initiate and govern the immune response, they represent an ideal target for intervention aimed at modulating and potentiating immune responses against cancer and infectious diseases. We recently described and characterized, at a functional level, a novel DC subset, interferon (IFN)-DCs, derived from blood monocytes after a short exposure to type I IFN and GM-CSF. Here, we review our recent studies on IFN-DCs and discuss their possible use in clinical immunotherapeutic strategies.
Medical subject headings
- Cell Differentiation
- Dendritic Cells
- Immunotherapy
- Interferon Type I
- Monocytes