Adenoma multiplicity in irradiated Apc(Min) mice is modified by chromosome 16 segments from BALB/c.
basic_science · Level V
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Abstract
Ionizing radiation (IR) is a well-characterized carcinogen in humans and mice. The BALB/c mouse strain is unusually sensitive to IR-induced tissue damage and cancer development in a range of organs, suggestive of a partial defect in DNA damage response. This has been confirmed by finding BALB/c-specific functional polymorphism in Prkdc, a gene on mouse chromosome 16 that encodes the catalytic subunit of DNA-dependent protein kinase. Prkdc(BALB) has been associated with increased susceptibility to IR-induced mammary and lymphatic neoplasia. Here, we provide evidence that chromosome 16 segments from BALB/c interact with Apc(Min) (multiple intestinal neoplasia) and specifically enhance IR-induced adenoma development in the upper part of the small intestine.
Medical subject headings
- Adenoma
- DNA-Binding Proteins
- Intestinal Neoplasms
- Neoplasms, Radiation-Induced
- Protein Serine-Threonine Kinases