Computational modeling of arterial biomechanics: insights into pathogenesis and treatment of vascular disease.

Abstract

We review how advances in computational techniques are improving our understanding of the biomechanical behavior of the healthy and diseased cardiovascular system. Numerical modeling of biomechanics is being used in a wide variety of ways, including assessment of effects of mural and hemodynamically induced stresses on atherogenesis, development of risk measures for aneurysm rupture, improvement in interpretation of medical images, and quantification of oxygen transport in diseased and healthy arteries. Although not amenable to routine clinical use, numerical modeling of cardiovascular biomechanics is a powerful research tool.