Digoxin-carvedilol interactions in children.
case_series · Level IV
Where this comes from
- Record sourced from PubMed, PMID 12756393.
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Abstract
Digoxin is often coadministered with carvedilol in children with severe ventricular failure. In eight children (age 2 weeks to 8 years), the oral clearance of digoxin decreased by half with carvedilol, and two of them had digoxin toxicity. Carvedilol increases serum concentrations of digoxin in children, and its dose may need to be reduced to avoid toxicity.
Medical subject headings
- Carbazoles
- Cardiomyopathy, Dilated
- Cardiotonic Agents
- Digoxin
- Hypoplastic Left Heart Syndrome
- Propanolamines
- Vasodilator Agents