Fusion with the fused: a new role for interleukin-4 in the building of muscle.
editorial · Level V
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Abstract
In this issue of Cell, G. Pavlath and coworkers demonstrate a novel role for Interleukin-4 (IL-4) in regulating the fusion of myoblasts with differentiated myotubes. The authors demonstrate that NFATc2 signaling in newly formed myotubes induces IL-4 expression and secretion which promotes myoblast fusion with pre-existing myotubes.
Medical subject headings
- Cell Differentiation
- Interleukin-4
- Muscle Fibers, Skeletal
- Muscle, Skeletal
- Myoblasts, Skeletal