Graded positional information: interpretation for both fate and guidance.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 12757702.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Recent evidence indicates that gradients of the same extracellular molecules can act as both morphogens, specifying cell differentiation, and guidance cues, directing axon movement. We discuss how cells may use common mechanisms to convert graded information into discrete responses; and how extracellular signals provide coordinate systems that can be linked to highly diverse cellular outputs.
Medical subject headings
- Body Patterning
- Cell Differentiation
- Cell Lineage
- Growth Cones
- Spinal Cord
- Stem Cells