Therapeutic role of dual inhibitors of 5-LOX and COX, selective and non-selective non-steroidal anti-inflammatory drugs.
review · Level V
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- Record sourced from PubMed, PMID 12759283.
- Also identified by PMC identifier 1754580.
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Abstract
Dual 5-LOX/COX inhibitors are potential new drugs to treat inflammation. They act by blocking the formation of both prostaglandins and leucotrienes but do not affect lipoxin formation. Such combined inhibition avoids some of the disadvantages of selective COX-2 inhibitors and spares the gatrointestinal mucosa.
Medical subject headings
- Anti-Inflammatory Agents, Non-Steroidal
- Cyclooxygenase Inhibitors
- Lipoxygenase Inhibitors