Contrasting effects of IFNbeta and IVIG in children with central and peripheral demyelination.
case_series · Level IV
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- Record sourced from PubMed, PMID 12771272.
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Abstract
Reported are three children with MS who responded dramatically to interferon-beta (IFNbeta) therapy. While on immunomodulatory therapy, they developed chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) that responded to IV immunoglobulin (IVIG) administration. These cases emphasize two interesting observations: 1) IFNbeta treatment did not prevent development of CIDP; 2) CIDP in the context of MS responded to IVIG, even though IVIG had no therapeutic effect on the central demyelinating disease.
Medical subject headings
- Immunoglobulins, Intravenous
- Interferon-beta
- Multiple Sclerosis
- Polyradiculoneuropathy, Chronic Inflammatory Demyelinating