Contribution of stem cells and differentiated cells to epidermal tumours.
review · Level V
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- Record sourced from PubMed, PMID 12778134.
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Abstract
The outer covering of the skin--the epidermis--is subject to sustained environmental assaults. As a result, many cells acquire potentially oncogenic mutations. Most cells are lost through differentiation, and only long-term epidermal residents, such as stem cells, accumulate the number of genetic hits that are necessary for tumour development. So, what genetic and environmental factors determine whether a mutant stem cell forms a tumour and what type of tumour will develop?
Medical subject headings
- Cell Differentiation
- Epidermis
- Neoplastic Stem Cells
- Skin Neoplasms