Telomerase reactivation in malignant gliomas and loss of heterozygosity on 10p15.1.
retrospective_cohort · Level III
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Abstract
An inhibitor of telomerase activity maps to chromosome 10p15.1. A series of 51 high-grade gliomas was analyzed for loss of heterozygosity (LOH) on chromosome 10 and for telomerase activity. In univariate analysis, LOH10p (59%) and LOH10q (61%) were associated with telomerase activity (55%; p < 0.0001 and p = 0.0006). In multivariate analysis, only LOH10p remained statistically related to telomerase activity, suggesting that the telomerase repressor gene located on 10p15.1 is inactivated in high-grade gliomas.
Medical subject headings
- Chromosomes, Human, Pair 10
- Glioma
- Loss of Heterozygosity
- Telomerase