Gut and mind.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 12801943.
- Also identified by PMC identifier 1773696.
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Abstract
Obesity is a growing epidemic, causally associated with a number of serious medical conditions, including diabetes mellitus, coronary heart disease, and several cancers. The gut hormones ghrelin and peptide YY are secreted from the gut in response to changes to nutritional status. While food intake is stimulated by ghrelin, it is inhibited by peptide YY. The discovery, anatomy, and physiology of ghrelin and peptide YY are discussed, focusing on the adaptive changes in diseases such as obesity and anorexia nervosa. Ghrelin and PYY are important therapeutic targets in the quest to find an effective antiobesity treatment.
Medical subject headings
- Obesity, Morbid
- Peptide Hormones
- Peptide YY