Fusion of cells by flipped SNAREs.
basic_science · Level V
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- Record sourced from PubMed, PMID 12805548.
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Abstract
The SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor) hypothesis suggests that pairs of proteins known as vesicle (v-) SNAREs and target membrane (t-) SNAREs interact specifically to control and mediate intracellular membrane fusion events. Here, cells expressing the interacting domains of v- and t-SNAREs on the cell surface were found to fuse spontaneously, demonstrating that SNAREs are sufficient to fuse biological membranes.
Medical subject headings
- Antigens, Surface
- Cell Fusion
- Cell Membrane
- Membrane Proteins
- Nerve Tissue Proteins