AIP1: a new player in TNF signaling.
review · Level V
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- Record sourced from PubMed, PMID 12813014.
- Also identified by PMC identifier 161430.
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Abstract
Apoptosis signal-regulating kinase 1 (ASK1) is an upstream activator of JNK and p38 MAPK signaling cascades. Evidence now shows that the ASK1-interacting protein, AIP1, plays an important role in TNF-alpha-induced ASK1 activation by facilitating dissociation from its inhibitor.
Medical subject headings
- MAP Kinase Kinase Kinases
- Tumor Necrosis Factor-alpha
- ras GTPase-Activating Proteins