Glycyrrhizin, an active component of liquorice roots, and replication of SARS-associated coronavirus.
basic_science · Level V
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- Record sourced from PubMed, PMID 12814717.
- Also identified by PMC identifier 7112442.
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Abstract
The outbreak of SARS warrants the search for antiviral compounds to treat the disease. At present, no specific treatment has been identified for SARS-associated coronavirus infection. We assessed the antiviral potential of ribavirin, 6-azauridine, pyrazofurin, mycophenolic acid, and glycyrrhizin against two clinical isolates of coronavirus (FFM-1 and FFM-2) from patients with SARS admitted to the clinical centre of Frankfurt University, Germany. Of all the compounds, glycyrrhizin was the most active in inhibiting replication of the SARS-associated virus. Our findings suggest that glycyrrhizin should be assessed for treatment of SARS.
Medical subject headings
- Antiviral Agents
- Coronavirus
- Glycyrrhiza
- Glycyrrhizic Acid
- Virus Replication