Relative sparing of nitric oxide synthase-containing neurons in the hippocampal formation in Alzheimer's disease.
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Abstract
Nitric oxide (NO) is an endogenous neuromodulator that may mediate neurotoxic effects of glutamate. NO-synthesizing neurons are, however, resistant to NO- and glutamate-induced neurotoxicity. We now show that NO synthase neurons are selectively spared in patients with Alzheimer's disease, even in a severely affected region of the brain such as the hippocampal formation.
Medical subject headings
- Alzheimer Disease
- Amino Acid Oxidoreductases
- Hippocampus
- Neurons